EFFEX-HN TRIAL: STUDY PROTOCOL FOR A RANDOMIZED CONTROLLED TRIAL ON THE EFFECTIVENESS AND FEASIBILITY OF A COMPREHENSIVE SUPERVISED EXERCISE PROGRAM DURING RADIOTHERAPY IN HEAD AND NECK CANCER PATIENTS ON HEALTH-RELATED QUALITY OF LIFE

EffEx-HN trial: study protocol for a randomized controlled trial on the EFFectiveness and feasibility of a comprehensive supervised EXercise program during radiotherapy in Head and Neck cancer patients on health-related quality of life

Abstract Background With over 500,000 annually reported cases worldwide, head and neck cancer (HNC) is the seventh most common type of cancer worldwide.Treatment of HNC with chemoradiotherapy frequently results in serious impairments in physical and psychosocial functioning.Besides, HNC patients typically start their cancer treatment already with p

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Synovial Fibroblast Sialylation Regulates Cell Migration and Activation of Inflammatory Pathways in Arthritogenesis

Synovial fibroblasts have emerged as critical underlying factors to perpetuate chronic joint inflammation in Rheumatoid Arthritis.Like any other cell, synovial fibroblasts are covered with a complex layer of glycans that can change in response to extracellular signals, such as inflammation.We have previously shown that inflammatory synovial fibrobl

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